NCT03603444

Reliability of Serum Calcium to Phosphorus (Ca/P) Ratio as an Accurate and Inexpensive Tool to Define Disorders of Ca-P Metabolism

Serum Calcium to Phosphorus (Ca/P) Ratio to Define Disorders of Ca-P Metabolism

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 606 (actual)
• Sponsor: Azienda Ospedaliero-Universitaria di Modena · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: —

Summary

BACKGROUND: Primary hyperparathyroidism (PHPT) is the third most common endocrine disorder. The Ca/P ratio is an accurate tool to differentiate patients with PHPT (\>3.5 if Ca and P are expressed in mg/dl) from healthy subjects. The reliability of this index is based on the fact that serum Ca and P are inversely related together. However, other disorders of the Ca-P metabolism, such as hypophosphoremia (HypoP) not related to PHPT, might also impair the Ca/P ratio. OBJECTIVE: To validate the accuracy of Ca/P ratio in the diagnosis of Ca-P metabolism disorders, including also patients with documented HypoP not related to PHPT. METHODS: A single-center, retrospective, case-control study will be carried out. Biochemical measurements will include parathormone (PTH), vitamin D, serum Ca and P, serum albumin and creatinine.

Conditions

• Phosphorus and Calcium Disorders

Interventions

Type	Name	Description
OTHER	No intervention are provided

Timeline

• Start date: 2011-01-01
• Primary completion: 2018-01-01
• Completion: 2018-01-01
• First posted: 2018-07-27
• Last updated: 2018-07-27

Locations

1 site across 1 country: Italy