NCT03600311

Resistance Exercise and Protein During Weight Loss

Using Resistance Exercise and Protein Consumption to Protect Bone Health During Weight Loss

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 17 (actual)
• Sponsor: University of Nebraska Lincoln · Academic / Other
• Sex: All
• Age: 19 Years – 30 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine if post-exercise protein supplementation can rescue the anabolic response of muscle and bone to resistance exercise during caloric restriction.

Detailed description

1. Preliminary Testing Prior to the study start, participants will be weighed and body composition will be determined using bioimpedance analysis. Then participants will undergo a 5RM barbell back squat exercise testing procedure. 2. Randomization Participants will proceed through each of the following conditions lasting 3 days: CON: Participants will be in energy balance and consume 1.2 g protein/kg BW/day. Participants will be provided 30 g maltodextrin post-exercise. CR+C: Participants will be restricted to 15 kcal/kg FFM/day and consume 1.2 g protein/kg BW/day. Participants will be provided 30 g maltodextrin post-exercise. CR+P: Participants will be restricted to 15 kcal/kg FFM/day and consume 1.2 g protein/kg BW/day. Participants will be provided 30 g whey protein post-exercise. 3. Diet Prescription Dietary energy intake will be controlled using clinical products, maltodextrin and whey protein isolate to meet target energy intakes. Participants will receive calcium and Vitamin D supplementation throughout the study. 4. Exercise Prescription Participants will perform one bout of 5 sets of 5 repetitions of barbell back squat exercise on the morning of Day 3 each condition. Additional exercise and intense physical activity will be prohibited. 5. Assessments Body weight and composition (DXA + BIA), fasting blood draws for assessment of metabolic and anabolic hormones and questionnaires will be conducted before and after each condition. A 24-hour serial blood draw procedure will be conducted following each workout session on each Day 3. 6. Washout Once a participant completes a study condition, participants will continue to take daily body weights at home for up to one week. Then participants will be required to wait one more week before completing their next condition during which they will resume regular diet and physical activity.

Conditions

• Weight Loss
• Starvation

Interventions

Type	Name	Description
OTHER	Caloric Restriction	Participants will consume 15 kcal/kg FFM/day.
DIETARY_SUPPLEMENT	Post-Exercise Protein	Participants will ingest 30 g of protein following exercise.
OTHER	Energy Balance	Participants will consume 40 kcal/kg FFM/day.
DIETARY_SUPPLEMENT	Post-Exercise Carbohydrate	Participants will ingest 30 g of carbohydrate following exercise.
DIETARY_SUPPLEMENT	Calcium and Vitamin D	Participants will be supplied Calcium and Vitamin D supplements throughout the study period matched to the CON condition.

Timeline

• Start date: 2018-08-31
• Primary completion: 2019-05-01
• Completion: 2019-05-31
• First posted: 2018-07-26
• Last updated: 2019-06-12

Locations

1 site across 1 country: United States