NCT03599492

The Effect of Transjugular Intraheptic Portosystemic Shunt (TIPS) on Gastrointestinal Motility and the Gut Microbiota

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 14 (actual)
• Sponsor: NYU Langone Health · Academic / Other
• Sex: All
• Age: 18 Years – 99 Years
• Healthy volunteers: Not accepted

Summary

The effect of portal hypertension on gastrointestinal motility, and how reversal or improvement in portal hypertension may alter gastrointestinal motility, remains unclear and further research is needed. Additionally, patients with cirrhosis have altered gut microflora, particularly rich in lactobacilli, including enterococci and bifidobacteria. Transjugular Intraheptic Portosystemic Shunting (TIPS) is a procedure performed by interventional radiologists, in which a connection is made between the portal and venous circulations, allowing high pressure portal blood to more easily enter the systemic circulation and bypass the liver; thus effectively decreased portal pressure.

Conditions

• Cirrhosis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	SMART Pill Pre-TIPS	Assessment of motility with Smart Pill, which will be read and confirmed by gastroenterologist trained to interpret motility studies
DIAGNOSTIC_TEST	SMART Pill Post TIPS	Assessment of motility with Smart Pill, which will be read and confirmed by gastroenterologist trained to interpret motility studies

Timeline

• Start date: 2016-11-01
• Primary completion: 2022-04-12
• Completion: 2022-04-12
• First posted: 2018-07-26
• Last updated: 2022-08-09

Locations

1 site across 1 country: United States