NCT03597659

PheWAS of a Polygenic Predictor of Thyroid Function

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 37,154 (actual)
• Sponsor: Groupe Hospitalier Pitie-Salpetriere · Academic / Other
• Sex: All
• Age: 28 Years – 100 Years
• Healthy volunteers: Accepted

Summary

Performing a phenome-wide association study (PheWAS) identifying clinical diagnoses associated with a polygenic predictor of Thyroid stimulating hormone (TSH) levels identified by a previously published genome-wide association study (GWAS). PheWAS will be applied in an electronic-health-record (EHR) cohort including North American (n: 37,154) and European participants using 1,318 phenotypes.

Detailed description

Applying a genetic predictor of thyroid stimulating hormone levels to an electronic-health-record cohort to verify associations with thyroid disorders as positive controls, and identify new associations .

Conditions

• Thyroid
• Genetic Predisposition to Disease

Interventions

Type	Name	Description
GENETIC	phenome-wide association study (PheWAS)	Phenome-wide association study (PheWAS) identifying clinical diagnoses associated with a polygenic predictor of TSH levels identified by a previously published genome-wide association study (GWAS) which included North American and European participants. A phenome-wide scanning of 1,318 phenotypes will be performed, using a cohort of 37,154 North American individuals of European ancestry with electronic-health-record (EHR) data.

Timeline

• Start date: 2017-09-01
• Primary completion: 2018-07-01
• Completion: 2018-07-01
• First posted: 2018-07-24
• Last updated: 2019-09-26

Locations

1 site across 1 country: France