Trials / Completed
CompletedNCT03595969
Association Between Mitochondrial DNA Content and Risk of Acute Leukemia
Association Between Mitochondrial DNA Content and Risk of Acute Leukemia in Young Adult
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 300 (actual)
- Sponsor
- Air Force Military Medical University, China · Academic / Other
- Sex
- All
- Age
- 16 Years
- Healthy volunteers
- Accepted
Summary
Compelling epidemiological evidence indicates that alterations of mitochondrial DNA, including mutations and abnormal content of mitochondrial DNA (mtDNA), are associated with the initiation and development of acute lymphoblastic leukemia (ALL).The aim of this study was to explore association between mtDNA content in peripheral blood cells could be used as a risk predictor for ALL.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | Relative copy number of mitochondrial DNA | Mitochondria are responsible for multiple cellular functions including regulation of energy production, modulation of oxidation-reduction status, generation of reactive oxygen species and apoptosis. Each mitochondrion possesses multiple copies of a mitochondrial genome comprised of independently replicating double stranded DNA (mtDNA). |
Timeline
- Start date
- 2018-11-01
- Primary completion
- 2019-10-01
- Completion
- 2019-10-01
- First posted
- 2018-07-23
- Last updated
- 2020-07-10
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT03595969. Inclusion in this directory is not an endorsement.