NCT03593408

Pharmacokinetics of Sedatives and Analgesics During Extracorporeal Membrane Oxygenation (ECMO) Support

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 20 (estimated)
• Sponsor: Boston Children's Hospital · Academic / Other
• Sex: All
• Age: 0 Days – 17 Years
• Healthy volunteers: Not accepted

Summary

This study will measure plasma concentrations of dexmedetomidine, fentanyl, morphine and midazolam in pediatric patients supported with extracorporeal membrane oxygenation (ECMO) aiming to understand the pharmacokinetics of these drugs in this setting.

Conditions

• Drug Effect

Interventions

Type	Name	Description
DRUG	Dexmedetomidine	Administered for sedation management per hospital protocol
DRUG	Fentanyl	Administered for sedation management per hospital protocol
DRUG	Midazolam	Administered for sedation management per hospital protocol
DRUG	Morphine	Administered for sedation management per hospital protocol

Timeline

• Start date: 2019-02-08
• Primary completion: 2026-08-01
• Completion: 2026-12-01
• First posted: 2018-07-20
• Last updated: 2026-01-09

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study