NCT03593083

Acute Excposure of High Altitude on ECG and Non-invasive Blood Pressure.

Acute Exposure to Hypoxia in Precapillary Pulmonary Hypertension: Physiological and Clinical Effects at Rest and During Exercise

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 28 (actual)
• Sponsor: University of Zurich · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Randomized crossover trial in patients with Pulmonary Hypertension (PAH, CTEPH) to assess the acute response of High Altitude (Säntis, 2500m above sea level) on ECG repolarizations and non-invasive blood pressure measurements by Finapres® NOVA Technology.

Detailed description

Low altitude baseline measurements will be performed in Zurich (460m asl) including Echocardiography, Right heart catheterization, 6MWT, pulmonary function test, clinical assessment and blood gas Analysis. Randomly assigned to the order of testing, the participants will be tested in Low Altitude (Zurich, 470m) and at High Altitude (2500m). During the exposure High Alitude (2500m above sea level) and low alitude (Zurich) up to 5 hours, the participants' ECG and non-invasively assessed blood pressure by Finapres at rest and under exercise will be collected.

Conditions

• Pulmonary Hypertension

Interventions

Type	Name	Description
OTHER	Low altitude: 470m above sea level	Assessment at Low Altitude (in Zurich; 470m above sea level) in order to compare this data with High altitude exposure
OTHER	Säntis; 2500m above sea Level	Exposure to High Altitude (Säntis; 2500m above sea level) for approximately 5 hours

Timeline

• Start date: 2018-07-01
• Primary completion: 2019-01-01
• Completion: 2019-01-01
• First posted: 2018-07-19
• Last updated: 2020-01-07

Locations

1 site across 1 country: Switzerland