NCT03590886

Gut Microbes and Metabolic Group in Different PBC Patients for UDCA Response

A Clinical Study About Gut Microbes and Metabolic Group in Different PBC Patients for UDCA Response

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 60 (actual)
• Sponsor: Sun Yat-sen University · Academic / Other
• Sex: All
• Age: 30 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

To compare intestinal flora diversity in different PBC patients with UDCA responses, and further study the differences of bile acid metabolism and short chain fatty acid metabolism in feces and serum of two groups of PBC patients.

Detailed description

The PBC patients have been enrolled in the study for UDCA treatment more than 1 year, who is divided into the UDCA total response Group and the other poor response group according to Paris-I/II standard .The feces of two groups of patients were collected and the differences of microbial polymorphism of fecal microorganism in two groups were observed. The metabolic differences of bile acids and short chain fatty acids in serum and feces of two groups of PBC patients were studied by means of metabolic proteomics.

Conditions

• Primary Biliary Cirrhosis

Interventions

Type	Name	Description
OTHER	total response Group	biochemical response for UDCA treatment more than 1 year according to Paris-I/II standard

Timeline

• Start date: 2018-08-22
• Primary completion: 2018-12-31
• Completion: 2019-02-28
• First posted: 2018-07-18
• Last updated: 2019-12-24

Locations

1 site across 1 country: China