Trials / Completed
CompletedNCT03590496
Safety and Efficacy of Propionate for Reduction of LDL Cholesterol
Safety and Efficacy of PROPionatE for Reduction of LDL Cholesterol (PROPER-LDL Trial) - A Phase 2 Randomized Placebo Controlled Double-blind Trial
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 62 (actual)
- Sponsor
- Charite University, Berlin, Germany · Academic / Other
- Sex
- All
- Age
- 20 Years – 70 Years
- Healthy volunteers
- Not accepted
Summary
The objective of the trial is to evaluate a potential impact of food supplements with the short chain fatty acid propionate on blood LDL cholesterol level.
Detailed description
62 patients with low cardiovascular risk will be 1:1 randomized to receive either placebo (b.i.d.) or 500mg of propionate (b.i.d.). The primary endpoint is the change (delta) in blood LDL cholesterol levels after 8 weeks.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIETARY_SUPPLEMENT | Calcium-Propionate 500mg | Calcium-Propionate capsules |
| OTHER | Placebo | Placebo capsules without any active ingredient |
Timeline
- Start date
- 2018-07-25
- Primary completion
- 2020-06-30
- Completion
- 2020-06-30
- First posted
- 2018-07-18
- Last updated
- 2020-09-16
Locations
1 site across 1 country: Germany
Source: ClinicalTrials.gov record NCT03590496. Inclusion in this directory is not an endorsement.