NCT03587753

Experiment 2: Understanding Liver Fat Metabolism

Understanding Liver Fat Metabolism: Studies to Understand the Role of Dietary Nutrients on Liver Fat Metabolism

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: University of Oxford · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

There is a largely unsubstantiated thought in the literature that dietary unsaturated enter oxidation pathways preferentially compared to saturated fatty acids. This study is undertaking a direct comparison of the oxidation of dietary saturated and unsaturated fatty acids.

Detailed description

Provided subjects meet the inclusion criteria, then at least one week after the screening visit volunteers will then undertake the first two 'study days'. There will be two study days on separate occasions that will be up to 3 weeks apart. Each study day will be approximately 7 hours in duration. On each study day participants will be given a standardised 'test' meal that contains specially labelled fat molecules (stable-isotope tracer) and then repeated breath and blood samples will be taken over the course of the next 6 hours. The test meal consumed on each 'study day' will be identical in composition with only the specially labelled fat molecules being different (either unsaturated or saturated fat) and these will be given in a random order.

Conditions

• Fatty Acid Oxidation

Interventions

Type	Name	Description
OTHER	Dietary fatty acid partitioning	There is no intervention as such, just a physiological assessment of the partitioning and oxidation of two different types of dietary fatty acids

Timeline

• Start date: 2018-05-01
• Primary completion: 2021-01-01
• Completion: 2021-01-01
• First posted: 2018-07-16
• Last updated: 2022-06-07

Locations

1 site across 1 country: United Kingdom