NCT03587324

Perioperative Aspirin Response in Patients Undergoing Vascular Surgery

Perioperative Risk Factors for the Development of Aspirin Low Response in Patients Undergoing Vascular Surgery.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 176 (actual)
• Sponsor: St. Josef Hospital Bochum · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Reduced antiplatelet activity (low response (LR)/high on-treatment platelet reactivity (HPR)) of aspirin (ALR) or clopidogrel (CLR) is associated with an increased risk of thromboembolic events. The prevalence figures for low-responders reported in the literature vary widely and there have been few investigations in vascular surgery patients to date. The aim of this prospective monocentric study was to increase the evidence base on vascular surgery patients and to detect any changes in the response following vascular surgery procedures.

Detailed description

The activity of aspirin (acetylsalicylic acid, ASA) and clopidogrel is measured by whole blood impedance aggregometry using a multiple electrode aggregometer (Multiplate). The agonists used are arachidonic acid for aspirin and adenosine diphosphate (ADP) for clopidogrel. Vascular patients requiring treatment for peripheral artery disease (PAD) and/or carotid stenosis are included in the study. To identify possible risk factors demographic data, concomitant medication, laboratory parameters, co-morbidities, severity of the condition and the type of procedure performed are documented. In addition, a follow-up aggregometry is performed after completion of the vascular procedure.

Conditions

• Vascular Surgery Patient With PAD / Carotid Stenosis

Interventions

Type	Name	Description
DRUG	Whole blood aggregometry before and after vascular treatment (ASA/ Clopidogrel).	To identify possible risk factors demographic data, concomitant medication, laboratory parameters, co-morbidities, severity of the condition and the type of procedure performed are documented. Other Name: ASA (aspirin), Clopidogrel (Plavix)

Timeline

• Start date: 2013-02-01
• Primary completion: 2015-03-01
• Completion: 2015-03-01
• First posted: 2018-07-16
• Last updated: 2018-07-18

Locations

1 site across 1 country: Germany