NCT03584841

Implementation of a Non-invasive Version of the Imaging β-adrenergic-dependent Sweat Secretion Test

Implementation of a Non-invasive Version of the Imaging β-adrenergic-dependent Sweat Secretion Test: Value for Diagnosis and Efficacy of Target Therapies for Cystic Fibrosis

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (estimated)
• Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: Accepted

Summary

The goal of this study is to implement a non-invasive version of the sweat secretion test based in visualization of sweat glands following β-adrenergic stimulation of sweat. Specifically, the trial will evaluate the relative response of sweat glands to β-adrenergic and cholinergic stimulation among participants with CF, heterozygous and matched control subjects

Conditions

• Mucoviscidosis Involving the Lung

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Iontophoresis sessions in forearm of subjects with pilocarpine	The test with two iontophoresis sessions is performed in a forearm of subjects. Pilocarpine is applied during the first iontophoresis session to evoke cholinergic-induced sweat secretion. Atropine, isoprenaline and aminophylline are applied during the second iontophoresis session, to block the cholinergic component and to evoke β-adrenergic-induced sweat secretion.

Timeline

• Start date: 2017-03-31
• Primary completion: 2021-12-31
• Completion: 2021-12-31
• First posted: 2018-07-12
• Last updated: 2021-03-24

Locations

1 site across 1 country: Belgium