NCT03583762

Time to Appropriate Antibiotic Between Using Microarray Assay and Mass Spectrometry Technique

Comparison of Time to Appropriate Antibiotic Between Using Microarray Assay and Mass Spectrometry Technique for Identification of Positive Blood Cultures

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 200 (estimated)
• Sponsor: Chiang Mai University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is an experimental study of participants who had positive blood culture to compare time to appropriate antibiotic between using Microarray Assay and Mass Spectrometry to bacterial Identification.

Detailed description

Between June to Dec 2018, 200 participants those met the eligibility criteria were enrolled in this study that is a quasi experimental study. All participants were empirical antibiotic therapy by infectious physician. 100 patients in Pre-intervention group had bacterial identification by Mass spectrometry technique from bacterial colony and 100 patients in Post-intervention group had bacterial identification by Microarray assay from blood culture. Antibiotic adjustment were considered after bacterial identification and result of antibiotic susceptibility testing. Then all participants were re-evaluated outcome after treatment. Finally, the results were ready to analysis in January 2019.

Conditions

• Septicemia

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Mass spectrometry	Molecular diagnostic test for bacterial identification from bacterial colony
DIAGNOSTIC_TEST	Microarray assay	Bacterial identification by Microarray assay from positive blood culture and confirmed by Mass spectrometry technique from bacterial colony. Adjusted antibiotic therapy according to AST Re-evaluation after treatment

Timeline

• Start date: 2018-07-30
• Primary completion: 2018-12-31
• Completion: 2019-03-31
• First posted: 2018-07-11
• Last updated: 2018-07-11

Locations

1 site across 1 country: Thailand