NCT03583684

Neuroimaging Predictors of Improvement to Pivotal Response Treatment (PRT) in Young Children With Autism

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 36 (estimated)
• Sponsor: Stanford University · Academic / Other
• Sex: All
• Age: 2 Years – 4 Years
• Healthy volunteers: Not accepted

Summary

Autism spectrum disorder (ASD) is a very heterogeneous disorder with limited empirically validated behavioral and biological interventions. The goal of this pilot investigation is to apply a biologically-based approach to identify predictors of treatment response in children with ASD who are receiving Pivotal Response Treatment (PRT), an evidence-based behavioral intervention. Specifically, the investigators propose to identify neuroimaging biomarkers of treatment response to a PRT program (PRT-P) targeting language deficits in young children with ASD who will be randomized to either PRT-P or to a delayed treatment group (DTG).

Conditions

• Autism Spectrum Disorder
• Autism

Interventions

Type	Name	Description
BEHAVIORAL	Pivotal Response Treatment Program (PRT-P)	The Pivotal Response Treatment Program (PRT-P) will consist of 3 parent-only sessions (60-90 min) and 13 family sessions with the parent and child (60-90 min). These 16 sessions are once per week over a 16 week period.

Timeline

• Start date: 2018-12-07
• Primary completion: 2026-11-30
• Completion: 2026-11-30
• First posted: 2018-07-11
• Last updated: 2025-11-10

Locations

1 site across 1 country: United States