NCT03583580

Accelerated Partial Breast Irradiation With IMRT in Early Breast Cancer

A Multicenter Phase Ⅱ Prospective Clinical Trial of Accelerated Partial Breast Irradiation With IMRT After Breast-conserving Surgery in Early Breast Cancer

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 537 (estimated)
• Sponsor: Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Academic / Other
• Sex: Female
• Age: 45 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

This study is to evaluate the efficacy and toxicity of accelerated partial breast irradiation (ABPI) with intensity modulated radiation therapy (IMRT) in low-risk breast cancer treat with breast-conserving surgery.

Detailed description

This study is a national multicenter phase II prospective clinical trial to enroll low-risk breast cancer treat with breast-conserving surgery. All eligible patients will receive ABPI to a total dose of 40Gy, in 10 fractions, 4Gy/fx/day, within 2 weeks. Intensity modulated radiation therapy (IMRT) technique is used. During Follow up, the locoregional recurrence,survival,acute and late adverse events,and quality of life will be prospectively evaluated.

Conditions

• Breast Neoplasms
• Neoplasm Recurrence, Local

Interventions

Type	Name	Description
RADIATION	Accelerated Partial Breast Irradiation	Patients are irradiated to the region of tumour bed using intensity modulated radiation therapy (IMRT)

Timeline

• Start date: 2017-06-19
• Primary completion: 2026-01-01
• Completion: 2026-06-01
• First posted: 2018-07-11
• Last updated: 2026-01-12

Locations

1 site across 1 country: China