Trials / Completed
CompletedNCT03582826
Microbial Basis of Systemic Malodor and "People Allergic To Me" Conditions
Dynamics of the Gut Microbiota in Idiopathic Malodor Production
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 125 (actual)
- Sponsor
- Mebo Research, Inc. · Academic / Other
- Sex
- All
- Age
- 18 Years – 110 Years
- Healthy volunteers
- Not accepted
Summary
The purpose of this study is to identify microbial signatures associated with remission and recurrence of idiopathic malodor and PATM conditions.
Detailed description
Human odorprints, mostly owing to the microbiome, have proven their value as biomarkers of health and environmental exposures. In recent years, microbial networks responsible for localized malodors such as halitosis or axillary odor have been mapped by using next generation sequencing approaches. Intestinal microbes responsible for psychologically debilitating systemic malodor (whole-body and extraoral halitosis), however, remain to be identified. Even a relatively straightforward disorder of choline metabolism trimethylaminuria (TMAU) is thought to exhibit complex host-gene microbiome interactions and has not been sufficiently studied. Proposed controlled pilot study aims to explore the dynamics of microbial communities in remission and flare-up periods. Better knowledge of the important aspects of disease fluctuation should enhance patient care and, combined with our prior data, will help to develop new therapies and treatments.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| BEHAVIORAL | Nutritional counselling | Behavioral nutritional counselling delivered via the Internet. |
| BEHAVIORAL | Stress-reduction counseling | The psycho-behavioral intervention includes administering questionnaires and monthly maintenance psychological support delivered via the Internet. |
Timeline
- Start date
- 2018-06-16
- Primary completion
- 2019-06-16
- Completion
- 2020-02-10
- First posted
- 2018-07-11
- Last updated
- 2021-01-05
- Results posted
- 2021-01-05
Locations
2 sites across 2 countries: United States, United Kingdom
Source: ClinicalTrials.gov record NCT03582826. Inclusion in this directory is not an endorsement.