NCT03581604

De-labeling of Patients With False Diagnosis of Penicillin Allergy

Diagnostic De-labeling of Patients With False Diagnosis of Penicillin Allergy: A Tool for Improving Antimicrobial Treatment and Reducing Antimicrobial Resistance

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 200 (estimated)
• Sponsor: Oslo University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to estimate the prevalence of penicillin allergy, evaluate the diagnostic value of the allergologic work-up used in the study, and the health effects of penicillin allergy.

Detailed description

Penicillin allergy is the most common of self-reported drug allergies and un-verified penicillin allergy is a significant and growing public health problem. 10% of all patients report penicillin allergy. However, there is large discrepancy between reported penicillin allergy and true allergy. Despite its high prevalence, greater than 90% of such patients are in fact able to tolerate the medication without allergic reactions. In this study patients having a penicillin allergy label will be investigated to confirm or to exclude the allergy diagnosis. The diagnostic value of the allergen test panel and the allergologic work-up will be evaluated. Clinical parameters as well as immunological will be assessed.

Conditions

• Allergy Drug

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Allergy work-up	Allergy work-up
OTHER	Blood samples	Blood samples

Timeline

• Start date: 2017-09-13
• Primary completion: 2023-12-01
• Completion: 2026-12-31
• First posted: 2018-07-10
• Last updated: 2023-11-03

Locations

1 site across 1 country: Norway