NCT03579914

Effect of Intravenous Metoprolol Combining RIC on Myocardial Protection in STEMI Patients

Combined Metoprolol and Remote Ischemic Conditioning in Cardioprotection of Anterior ST-segment Elevation Myocardial Infarction (METRICATION)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 1,206 (actual)
• Sponsor: Harbin Medical University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The main purpose of this study is to compare the myocardial protection effect of intravenous metoprolol combined with remote ischemic conditioning (RIC) and single treatment before reperfusion in Chinese patients with anterior STEMI. This study sought to find possible strategies to further improve myocardial protection in Chinese patients with anterior STEMI.

Detailed description

This study is a prospective, multi-center, randomized controlled study. It is planned to enroll 1200 patients with anterior STEMI. Immediately after the first medical contact, the patients who were determined by the investigator to meet the inclusion/exclusion criteria were randomized through the interactive web response system (IWRS) and received different pre-reperfusion treatments. The four groups were placebo group, metoprolol group, remote ischemic conditioning (RIC) group and metoprolol \& RIC group. Subsequently, the investigator conduct diagnosis and treatment according to the patient's specific conditions and check the serum level of myocardial damage markers (i.e. CK and CK-MB) at the time of admission, 12, 24, 36, 48, 60 hours, respectively. If the patient undergoes PCI treatment, additional detection of myocardial damage markers immediately after PCI is also required. All patients were followed for 1 year with an office visit or a telephone call at 1, 3, 6, 9 and 12 months to evaluate the health status and adverse clinical events of patients.

Conditions

• Anterior Myocardial Infarction
• Heart Failure

Interventions

Type	Name	Description
DRUG	intravenous Placebo	Patients receive intravenous Placebo (saline) injection
DRUG	Metoprolol Injectable Product	Patients receive intravenous Metoprolol injection
DEVICE	Romote Ischemic Conditioning (RIC)	Patients receive RIC treatment
COMBINATION_PRODUCT	Metoprolol & RIC	Patients receive Metoprolol \& RIC treatment

Timeline

• Start date: 2017-11-28
• Primary completion: 2020-08-31
• Completion: 2021-08-30
• First posted: 2018-07-09
• Last updated: 2021-11-04

Locations

16 sites across 1 country: China