NCT03577457

The Interaction Between Oxytocin and Serotonin

The Interaction Between Oxytocin and Serotonin on the Social-reward Brain Networks and Decision Making

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: University of Electronic Science and Technology of China · Academic / Other
• Sex: Male
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

The primary objective of this study is to identify any interaction between oxytocin and serotonin on neural and behavioral activity related to social reward and decision making by a double-blind, placebo-controlled, between-subject, pharmacological fMRI design

Detailed description

Serotonin and oxytocin have been proved to play an important role in social reward processing and decision making in human. The aim of this study is to determine whether they interact in those essential human behaviors by a double-blind, placebo-controlled, between-subject, pharmacological fMRI design, in which 4 groups of healthy males will be administered with a random combination of nasal oxytocin (24 international units, IU) or placebo and acute tryptophan depletion (ATD, 75.2g) or placebo (a tryptophan-balanced mixture, 78.2g). The social-reward related neural activity and behavior will be assessed by a series of social reward task in and out of fMRI scanner and the decision making will be assessed by reversal learning task, ultimatum game (UG) and loss aversion task. The interaction between serotonin and oxytocin on brain networks will also be tested by resting state.

Conditions

• Healthy

Interventions

Type	Name	Description
DRUG	oxytocin nasal spray	intranasal administration of oxytocin (24 IU)
DRUG	ATD treatment	oral administration of ATD (75.2g) (Acute Tryptophan Depletion)
DRUG	intranasal placebo treatment (placebo-control for oxytocin)	intranasal administration of placebo nasal spray
DRUG	oral placebo treatment (placebo-control for ATD)	oral administration of a tryptophan-balanced mixture (78.2g)

Timeline

• Start date: 2018-02-01
• Primary completion: 2019-06-20
• Completion: 2019-07-20
• First posted: 2018-07-05
• Last updated: 2018-07-12

Locations

1 site across 1 country: China