Trials / Completed
CompletedNCT03577249
Biological Effects of Citrate-buffered Solutions on Dialysis Efficiency and Systemic Inflammation
- Status
- Completed
- Phase
- Phase 2 / Phase 3
- Study type
- Interventional
- Enrollment
- 45 (actual)
- Sponsor
- A.O.U. Città della Salute e della Scienza · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
In this study 45 patients undergoing weekly dialysis for chronic end stage renal disease will be enrolled. The patients will be treated with a standard dialysis solution, containing acetate buffer, for 3 months; subsequently the acetate will be substituted with citrate anion for the 3 following months and then, the last 3 months, the standard acetate-solution will be restarted. The aim of the study is to assess if acetate-to-citrate switch in the dialysis solution influences dialysis efficiency and patient inflammatory state.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Dialysis Solutions | Solution A: 3mmol/L of acetate anion; Solution B: 1mmol/L of citrate anion |
Timeline
- Start date
- 2014-10-30
- Primary completion
- 2015-07-30
- Completion
- 2015-07-30
- First posted
- 2018-07-05
- Last updated
- 2018-07-09
Locations
1 site across 1 country: Italy
Source: ClinicalTrials.gov record NCT03577249. Inclusion in this directory is not an endorsement.