NCT03576118

Moderate vs Deep Neuromuscular Block on Biotrauma During Laparoscopy

The Effects of Moderate Versus Deep Neuromuscular Block on Respiratory Mechanics and Biotrauma in Patients With Intraoperative Protective Lung Ventilation for Laparoscopy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 74 (actual)
• Sponsor: Ajou University School of Medicine · Academic / Other
• Sex: All
• Age: 25 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purposes of this study is to investigate the effects of moderate vs. deep neuromuscular block on respiratory mechanics and biotrauma in patients with intraoperative protective lung ventilation for laparoscopy.

Detailed description

Mechanical ventilation results in the disruption of the alveolar-capillary barrier and increased permeability, a hallmark of experimental ventilator-induced lung injury. These mechanical forces also induce an increase in the concentrations of inflammatory cytokines. The benefits of deep neuromuscular blocks for laparoscopic procedures are controversial and most of the studies undertaken have only sought to improve surgical conditions. Theoretically, deep neuromuscular block permits a lower abdominal insufflation pressure, which leads to better respiratory mechanics and gas exchange. The investigators examined the effects of moderate vs. deep neuromuscular block on respiratory mechanics and biotrauma in patients with intraoperative protective lung ventilation for laparoscopy. The investigators hypothesized that deep neuromuscular block (PTC 1 or 2) and low pressure pneumoperitoneum (8 mmHg) would improve respiratory mechanics and reduce inflammatory processes associated with biotrama during mechanical ventilation compared with moderate neuromuscular block (TOF count 1 or 2 ) and standard pressure pneumoperitoneum (12-15 mmHg).

Conditions

• Pneumoperitoneum

Interventions

Type	Name	Description
DRUG	Deep neuromuscular block	Deep neuromuscular block using high dose rocuronium and 8 mmHg pneumoperitoneum
DRUG	Moderate neuromuscular block	Moderate neuromuscular block using moderate dose rocuronium and 12-15 mmHg pneumoperitoneum

Timeline

• Start date: 2018-11-05
• Primary completion: 2019-07-12
• Completion: 2019-09-19
• First posted: 2018-07-03
• Last updated: 2020-06-11
• Results posted: 2020-06-11

Locations

1 site across 1 country: South Korea