NCT03576053

A Mechanistic Evaluation of the Interactions Between Thermoceptive and Pruriceptive Sensory Processing

En Mekanistisk undersøgelse af Interaktioner Imellem Det Thermoceptive og Det Pruriceptive Sensoriske System

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 59 (actual)
• Sponsor: Aalborg University · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The purpose of this human experimental study is to evaluate the pattern of itch intensity over time in response to strong, short-term heat stimulation in two different models of histamine and cowhage-induced itch. Moreover, the purpose is to evaluate the effect of mild pre-heating of the skin in human experimental models of histamine, cowhage and serotonin. Finally, we want to investigate the effect of short-term intense heat stimulation on previously anesthetized skin.

Conditions

• Itch
• Thermal Stimulation
• Histamine
• Cowhage
• Serotonine

Interventions

Type	Name	Description
DRUG	Lidocaine	Lidocaine intradermal injection
OTHER	Histamine	Skin Prick Test with Histamine
OTHER	Cowhage	Manually skin insertion of cowhage spicules
OTHER	Heat stimulation	Short heat stimulation
OTHER	Pre-heating	Mild skin pre-heating
OTHER	Serotonin	Serotonin electrophoresis

Timeline

• Start date: 2018-07-01
• Primary completion: 2019-07-31
• Completion: 2019-08-28
• First posted: 2018-07-03
• Last updated: 2020-07-08

Locations

1 site across 1 country: Denmark