NCT03575663

The Asthma Bronchial Challenge Study

Bronchial Challenge Testing in Asthma: The Effect of Mannitol Dry Powder Inhalation on Volatile Organic Compounds in Exhaled Breath

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 46 (actual)
• Sponsor: University of East Anglia · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This is a randomised, controlled, cross-over study to determine the effect of indirect bronchial challenge testing upon volatile organic compounds (VOCs) in the exhaled breath of adults with well-controlled, mild-to-moderate asthma. Participants will undergo baseline evaluation including clinical history, spirometry, exhaled nitric oxide measurement (FeNO), phlebotomy (blood eosinophil count), and sampling of exhaled breath VOCs. Participants will be randomised to receive either an indirect bronchial challenge test using mannitol dry powder (MDP) or a sham bronchial challenge, followed by further sampling of breath VOCs. The study will consist of a consent visit and two assessment visits with participants allocated to receive one of the two challenges (MDP or sham) at each assessment. Data will be analysed to determine the effect of bronchial challenge upon exhaled breath VOC profiles.

Conditions

• Asthma

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Indirect bronchial challenge	Mannitol dry powder inhalation
OTHER	Sham bronchial challenge	Mock dry powder inhalation

Timeline

• Start date: 2018-04-25
• Primary completion: 2019-02-19
• Completion: 2019-02-28
• First posted: 2018-07-02
• Last updated: 2019-04-25

Locations

1 site across 1 country: United Kingdom