NCT03573414

Gut Microbial Metabolism of Polyphenols and Cardiovascular Health (StratiPol) (Stratification Study)

Gut Microbial Metabolism of Polyphenols and Cardiovascular Health

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 250 (estimated)
• Sponsor: King's College London · Academic / Other
• Sex: All
• Age: 20 Years – 70 Years
• Healthy volunteers: Accepted

Summary

There is increasing interest in the effects of various food derived polyphenols on cardiovascular health. Several studies have demonstrated improvements in vascular function after intake of polyphenol rich foods. The objective of this study is to investigate the association between polyphenol microbiota metabolism and cardiovascular health. The participants (n=250) with age range between 20 to 70 years old health overweight men and women. The participants will consume a polyphenol rich breakfast for three days (consisting on milled flaxseed, raspberry powder and soy milk). The participants will provide the investigators with urine and blood samples for polyphenol analysis. Cardiovascular measurements such as PWV, AIx, Blood Pressure and FMD will be performed at baseline and after 72h.

Conditions

• Healthy

Interventions

Type	Name	Description
OTHER	raspberry powder, milled flaxseed and soy milk	* The participants will consume a breakfast consisting of 30 g of milled flaxseed, 40 g of raspberry powder and 250 ml of soy milk for 3 days * The participants will provide blood and urine samples

Timeline

• Start date: 2018-07-02
• Primary completion: 2022-09-01
• Completion: 2022-09-01
• First posted: 2018-06-29
• Last updated: 2022-03-31

Locations

1 site across 1 country: United Kingdom