NCT03573154

Nicotine Pharmacokinetic in Blood and Analysis of Exhaled Breath After E-cigarette Smoking.

Nicotine Pharmacokinetic Study and Volatile Organic Compound Analysis in Exhaled Breath After Electronic Cigarette Utilization.

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: University Hospital, Strasbourg, France · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

Electronic or e-cigarettes are battery-powered devices that deliver vapor which may be inhaled in the manner tobacco is smoked. The e-liquid is usually a solution containing propylene glycol and/or vegetable glycerin, nicotine, and flavor concentrates, although some e-liquids also are sold as non-nicotine containing products. The long- and short-term public health consequences of e-cigarette use, including the effects of e-cigarettes on tobacco use behavior, are not well understood. However, the prevalence of e-cigarette use appears to be undergoing a rapid increase. In this study the investigators propose to analyze nicotine pharmacokinetic in blood and to compare the exhaled breath before and after e-cigarette smoking. They want to obtain a pharmacokinetic model of this population for nicotine. And they want to identify if molecules contained in vapor are absorbed, metabolized or modified by the organism.

Conditions

• Electronic Cigarette

Interventions

Type	Name	Description
OTHER	administration of the liquid 1 and then the liquid 2	The patient will received the e-liquid 1 in the first visit and the e-liquid 2 in the second
OTHER	administration of the liquid 2 and then the liquid 1	The patient will received the e-liquid 2 in the first visit and the e-liquid 1 in the second

Timeline

• Start date: 2018-12-19
• Primary completion: 2022-06-15
• Completion: 2022-08-03
• First posted: 2018-06-29
• Last updated: 2021-12-23

Locations

1 site across 1 country: France