NCT03572270

HIV and Ovarian Reserve

Evaluation of the Potential Impact of HIV and Its Treatments on Ovarian Reserve: Prospective Study

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: University Hospital, Clermont-Ferrand · Academic / Other
• Sex: Female
• Age: 18 Years – 37 Years
• Healthy volunteers: Accepted

Summary

Recent evidence suggests a decline in fertility of persons living with HIV (PLWH) (delayed pregnancies, sponteanous abortions, especially when patients receive an antiretroviral therapy, early menopause, amenorrhea and anovulatory cycles) with a possible decrease in ovarian reserve. However, indications of fertility preservation by freezing oocytes are nevertheless not clearly identified. The objective of this study is to evaluate the ovarian reserve before and after the implementation of antiretroviral treatment in PLWH for whom the diagnosis of HIV has just been made.

Detailed description

This is a monocentric prospective cohort study with minimal risk and constraints. Ovarian reserve is compared between two groups: 30 PLWH, at time of diagnosis and 6, 12 and 18 months after initiation of an antiretroviral therapy, and 30 HIV negative women attending medically assisted procreation consultation for male infertility, age, BMI and smoking habits matched.

Conditions

• HIV
• Infertility

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	AMH test	Blood test and pelvic ultrasound are performed at each visit to evaluate ovarian reserve
DIAGNOSTIC_TEST	pelvic ultrasound	Blood test and pelvic ultrasound are performed at each visit to evaluate ovarian reserve

Timeline

• Start date: 2018-06-01
• Primary completion: 2022-06-01
• Completion: 2022-11-01
• First posted: 2018-06-28
• Last updated: 2018-06-28

Locations

1 site across 1 country: France