NCT03570645

Comparison of the Duration of Ropivacaine Combined With Dexmedetomidine or Dexamethasone on Paravertebral Block

Comparison of the Duration of Ropivacaine Combined With Dexmedetomidine or Dexamethasone on Paravertebral Block in Patients Undergoing Video-assisted Thoracic Surgery

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 154 (actual)
• Sponsor: China Medical University, China · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This study was a prospective, randomized, controlled, and double-blind trial. Major assessments were made during the operation and 48 h postoperatively.

Detailed description

The prime outcomes were the time in minutes from leave the postoperative care unit to the first patient-controlled intravenous analgesia press.The secondary outcomes were to compare the following: (1)blood concentrations of ropivacaine was measured at 0.5 h, 1 h, 2 h, 3 h, and 24 h after paravertebral nerve block; and (2) the patient's intraoperative opioid use, phenylephrine use, fluid intake, urine output, dry mouth score, and 24 h and 48 h visual analogue scale.

Conditions

• Lung Cancer

Interventions

Type	Name	Description
DRUG	Dexmedetomidine Group	combination of ropivacaine and dexmedetomidine 100 ug every time
DRUG	dexamethasone group	combination of ropivacaine and dexamethasone 10mg every time
DRUG	control group	block with only ropivacaine

Timeline

• Start date: 2019-07-12
• Primary completion: 2019-11-11
• Completion: 2019-11-18
• First posted: 2018-06-27
• Last updated: 2019-11-20

Locations

1 site across 1 country: China