NCT03570164

Hemodynamics for Equi-MAC Anesthesia

Comparison of Vasodilative Effects Between Sevoflurane and Desflurane Using Peripheral Perfusion Index

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 70 (actual)
• Sponsor: Kangbuk Samsung Hospital · Academic / Other
• Sex: All
• Age: 19 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to compare the peripheral perfusion index values produced by equi-MAC of sevoflurane and desflurane in patients undergoing single-agent inhalation anesthesia.

Detailed description

Ether derivative anesthetics, including sevoflurane and desflurane, have direct activity on vascular tissue and both are vasodilators. However, there has been no direct comparison of vasodilative effect between sevoflurane and desflurane in vivo in humans. Peripheral perfusion index derived from photoplethysmographic waveform reflects peripheral vasomotor tone. Therefore, the purpose of this study is to compare the peripheral perfusion index values produced by sevoflurane and desflurane at equipotent concentration in patients undergoing single-agent inhalation anesthesia.

Conditions

• Anesthesia

Interventions

Type	Name	Description
DRUG	Sevoflurane	End-tidal concentration of sevoflurane is maintained at age-corrected 1.0 minimum alveolar concentration throughout the study period.
DRUG	Desflurane	End-tidal concentration of desflurane is maintained at age-corrected 1.0 minimum alveolar concentration throughout the study period.

Timeline

• Start date: 2018-06-18
• Primary completion: 2018-11-13
• Completion: 2018-11-13
• First posted: 2018-06-26
• Last updated: 2019-10-21

Locations

1 site across 1 country: South Korea