NCT03565133

Quinine and Food Intake

The Effect of Quinine on Food Intake: Oral Sham Feeding Versus Intragastric Delivery

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 42 (actual)
• Sponsor: Maastricht University Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Rationale: The appearance of tastants in the small intestine following food ingestion results in the onset of digestion and absorption but can also result in the activation of a negative feedback mechanism from different parts of the intestine to the stomach, the small intestine and to the central nervous system. These processes inhibit food processing, appetite sensations and food intake, and furthermore they increase feelings of satiety and satiation. In this study, we aim to investigate the effects of oral sham feeding and intragastric delivery of a bitter tastant (quinine) on ad libitum food intake, satiation, gastrointestinal symptoms, and heart rate variability. Objective: To investigate the effect of oral sham feeding and intragastric delivery of a bitter tastant on food intake. Secondary Objective(s): 1. To compare the effect of oral sham feeding and intragastric delivery of a bitter tastant on satiation. 2. To assess the effect of oral sham feeding and intragastric delivery of a bitter tastant on gastrointestinal symptoms/complaints. 3. To assess the effect of oral sham feeding and intragastric delivery of a bitter tastant on heart rate variability.

Conditions

• Obesity

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Quinine sham feeding quinine	Oral sham feeding with quinine
DIETARY_SUPPLEMENT	Gastric quinine	A gastric capsule containing quinine
DIETARY_SUPPLEMENT	Oral sham feeding placebo	Oral sham feeding with placebo (tap water)
DIETARY_SUPPLEMENT	Gastric placebo	A gastric capsule containing placebo (cellulose)

Timeline

• Start date: 2018-08-17
• Primary completion: 2019-08-15
• Completion: 2019-08-15
• First posted: 2018-06-21
• Last updated: 2019-11-18

Locations

1 site across 1 country: Netherlands