NCT03563378

Effects of Intraoperative Normal Saline vs Lactated Ringer on Outcomes in Pediatric Liver Transplantation

Effects of Intraoperative Normal Saline vs Lactated Ringer on Outcomes in Pediatric Liver Transplantation: A Double-blind Randomized Trial

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 200 (estimated)
• Sponsor: RenJi Hospital · Academic / Other
• Sex: All
• Age: 3 Months – 6 Years
• Healthy volunteers: Not accepted

Summary

Lactated Ringer(LR) has been extensively used to maintain and replace intravascular volume in a variety of anesthetic procedures. However, the utility of LR in pediatric with hepatic failure undergoing liver transplantation is unclear, because addition of exogenous lactate may increase lactate concentration. In addition,large amounts of normal saline(NS) which does not contain lactate can induce a hyperchloremic metabolic acidosis and have been asociated with adverse effects on kidney injury, coagulation, and death. Accordingly, the investigators performed a double-blinded randomized trial comparing the effects of intraoperative NS or LR on outcomes in pediatric receiving Liver transplantation.

Conditions

• Biliary Atresia Intrahepatic Syndromic Form

Interventions

Type	Name	Description
DRUG	Lactated Ringer	Patients will be administered Lactated Ringer's solution for intraoperative fluid management.
DRUG	Normal saline	Patients will be administered normal saline for intraoperative fluid management.

Timeline

• Start date: 2018-07-28
• Primary completion: 2020-05-27
• Completion: 2020-05-27
• First posted: 2018-06-20
• Last updated: 2018-06-20

Locations

1 site across 1 country: China