NCT03561623

Spinal Cord Gray Matter Imaging in Post Polio Syndrome

Quantitative Spinal Cord Gray Matter Imaging in Post Polio Syndrome

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 40 (estimated)
• Sponsor: University Hospital, Basel, Switzerland · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This is a longitudinal, observational study with the aims of comparing spinal cord gray matter areas in patients with Post-Polio Syndrome to age and sex matched healthy control subjects and to correlate atrophy with metrics of clinical disability.

Detailed description

Post-Polio syndrome (PPS) is characterised by new muscle weakness, pain, and fatigue several years to decades after the acute polio infection. Pathomechanisms are not yet fully understood. This is a longitudinal, observational study. The aims are (a) to detect spinal cord gray (and possibly) white matter atrophy in patients with Post Polio Syndrome in comparison to healthy age and sex matched control subjects both cross-sectionally and longitudinally and (b) to correlate spinal cord gray and white matter atrophy to metrics of clinical disability. Investigators will assess 20 patients with Post-Polio syndrome and 20 control subjects at baseline and 48 weeks by MRI and clinically including quantitative muscle strength assessments.

Conditions

• Post-polio Syndrome

Interventions

Type	Name	Description
OTHER	magnetic resonance (MR) Imaging	MRI of spinal cord and brain
OTHER	quantitative muscle force assessment	quantitative assessment of muscle force

Timeline

• Start date: 2017-05-22
• Primary completion: 2022-10-01
• Completion: 2022-10-01
• First posted: 2018-06-19
• Last updated: 2020-06-24

Locations

1 site across 1 country: Switzerland