NCT03561025

Diagnostic Potential of PET/MRI in Cardiac Sarcoidosis

Diagnostic Potential of PET/MRI in Cardiac Sarcoidosis: A Pilot Study Combining Advanced MRI and 18F-FDG and 18F-GE180 PET of the Myocardium

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 33 (actual)
• Sponsor: St. Olavs Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of the study is to find better and more specific non-invasive methods to diagnose and stage cardiac sarcoidosis with the use of advanced imaging modalities, simultaneous 3T MRI and PET. Cardiac sarcoidosis is a disease of possibly fatal outcome in young people. The use of a combined PET/MRI system with 18F-FDG and a new inflammation-tracer (18F-GE180) can become a future game changer. Sarcoid induced focal inflammation in myocardium should show high 18F-GE180 uptake. 18F-GE180 PET scans will give reliable data about inflammatory sarcoidosis activity in the myocardium. 18F-GE180 PET is expected to improve diagnostic accuracy compared to 18F-FDG-PET and/or contrast enhanced MRI.

Conditions

• Sarcoidosis
• Cardiomyopathies

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	18F-FDG-PET/MRI	Contrast-enhanced MRI scanning after injection of 18F-FDG
DIAGNOSTIC_TEST	18F-GE180-PET/MRI	Contrast-enhanced MRI scanning after injection of 18F-GE180

Timeline

• Start date: 2018-10-01
• Primary completion: 2020-10-01
• Completion: 2020-10-01
• First posted: 2018-06-19
• Last updated: 2020-11-18

Locations

1 site across 1 country: Norway