NCT03560583

Efficacy of Metoclopramide in Poor Ovarian Response IVF Patients

Efficacy of Metoclopramide in Poor Ovarian Response IVF Patients: a Randomised, Double-blind, Placebo-controlled Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Barzilai Medical Center · Academic / Other
• Sex: Female
• Age: 18 Years – 54 Years
• Healthy volunteers: Accepted

Summary

Poor ovarian response population of ART are considered the biggest challenge for providers. Hitherto, no one protocol has been proven to be effect in this subgroup of IVF patients. Metoclopramide belongs to the antiemetic group, used for motion sickness and during early gestation for hyperemesis gravidarum. The mechanism of action is antagonisim to dopamine receptors. We hypothesize than by blocking dopamine receptors and decreasing the dopaminergic tone there is a possibility to increase the sensitivity of ovarian response to gonadotropins during controlled ovarian stimulation and result in increased oocyte retrival.

Conditions

• Poor Responders in IVF

Interventions

Type	Name	Description
DRUG	Metoclopramide	Metoclopramide 10 mg BID
DRUG	Placebo Oral Tablet	Placebo 10 mg BID

Timeline

• Start date: 2021-05-05
• Primary completion: 2027-12-01
• Completion: 2028-07-01
• First posted: 2018-06-18
• Last updated: 2025-02-10

Locations

1 site across 1 country: Israel