NCT03560414

The Plasma Diafiltration Therapy of Hepatic Failure

Study of High - Flux Plasma Diafiltration Based on Plasma - Saved Mode in the Treatment of Patients With Hepatic Failure

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Fuzhou General Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

At present, there is no comparative study between the simple plasma exchange and plasma diafiltration (PDF), and no further exploration of optimal plasma dose in PDF treatment. Therefore, this prospective randomized cohort study aims to compare the safety and effectiveness of the tree groups（simple plasma exchange group, conventional PDF treatment group, less plasma PDF treatment group）by collecting SOFA score, 3-month survival rate, MELD score, and the times of artificial liver treatment , blood cell variables, cytokines(e.g. TNFα ), pre- and post-treatment plasma ammonia levels. Thus, it is to provide a safer and more effective artificial liver treatment with less plasma dose.

Conditions

• Hepatic Failure
• Plasma Exchange

Interventions

Type	Name	Description
PROCEDURE	simple plasma exchange	simple plasma exchange treatment
PROCEDURE	conventional PDF treatment group	conventional PDF treatment group
PROCEDURE	less plasma PDF treatment group	less plasma Plasma diafiltration treatment

Timeline

• Start date: 2018-06-01
• Primary completion: 2020-06-01
• Completion: 2020-12-01
• First posted: 2018-06-18
• Last updated: 2018-06-18

Locations

1 site across 1 country: China