NCT03555786

MEV for Retroclavicular Approach to Infraclavicular Block

Minimum Effective Volume of Bupivacaine for Retroclavicular Approach Brachial Plexus Block

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 45 (actual)
• Sponsor: Antalya Training and Research Hospital · Other Government
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

In this study, the primary objective was to estimate the minimum effective volume of bupivacaine 0.5% resulting in successful block in 90% of patients (MEV90) for ultrasound-guided retroclavicular approach to infraclavicular brachial plexus block.

Detailed description

A "biased coin up-and-down sequential design" will be applied to assess the minimum effective volume in 90% of patients for the retroclavicular brachial plexus block. The first subject received 25 ml 0.5% bupivacaine . Each subsequent patient received a dose that depended on the response of the previous one. If the previous block is successful, the block will be performed either by a reduction of the volume by 2.5 ml with a probability ß = 0.11 or by a same dose of the previous one with a probability 1-ß = 0.89 in the next patient.

Conditions

• Bupivacaine

Interventions

Type	Name	Description
OTHER	minimum effective volume	The determination of MEV90 and its 95% confidence interval (CI) will be based on a "biased coin up-and-down sequential design

Timeline

• Start date: 2018-06-01
• Primary completion: 2018-08-01
• Completion: 2018-09-01
• First posted: 2018-06-14
• Last updated: 2020-04-30

Locations

1 site across 1 country: Turkey (Türkiye)