NCT03549546

Expression of the Inhibitory Receptors on Lymphocytes T Cells After Lung Cancer Surgery.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 31 (actual)
• Sponsor: Centre Hospitalier Universitaire de Saint Etienne · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Postoperative pneumonia is one of the most common complications after lung cancer surgery and associated with a morbidity and mortality. Postoperative lymphopenia has been recently identified as one of risk factors for postoperative pneumonia. According to recent studies in polytrauma, cancer or septic shock, T cells dysfunction may be related to high expression of inhibitory receptors on lymphocytes.

Detailed description

This study will investigate prospectively TIM-3, PD-1 and CTLA4 expression on lymphocytes T cells before and after lung cancer surgery. Patients ≥ 18 years with no history of immunosuppressive state will be included.

Conditions

• Lung Cancer
• Surgery

Interventions

Type	Name	Description
BIOLOGICAL	Blood samples	Blood samples will be collected in patients undergoing lung cancer surgery: * before lung cancer surgery, * the next day lung cancer surgery, * 3 days after lung cancer surgery. They will be treated in flow cytometry.

Timeline

• Start date: 2018-06-14
• Primary completion: 2019-02-06
• Completion: 2019-02-12
• First posted: 2018-06-08
• Last updated: 2019-07-26

Locations

1 site across 1 country: France