NCT03548532

Embryo Culture At a Constant Temperature of 36.6°C or 37.1°C

Embryo Culture At a Constant Temperature of 36.6°C or 37.1°C: a Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 234 (actual)
• Sponsor: Universitair Ziekenhuis Brussel · Academic / Other
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

On the day of oocyte retrieval, participants will be randomized to stable culture at 37.1°C or 36.6°C with the ultimate aim of finding a difference in clincial pregnancies.

Detailed description

A previous study in our centre analysed stable embryo culture at 36.6°C and 37.1°C, on sibling oocytes. The primary aim was to analyse possible differneces in embryo development (utilization rate) up to day 5/6. In this study, the investigators found a high difference in clinical pregnancy rate between both groups (46.4% versus 77.4%). Since this study was not powered to find differences in clincial pregnancy rates between both groups, this RCT was especially powered as a superiority trial to find differences in clincial pregnancy rates between both groups. On the day of oocyte retrieval, patients will be allocated to culture at one of both temperatures.

Conditions

• Temperature; Extreme, Exposure

Interventions

Type	Name	Description
DEVICE	G210 incubator	very stable culture temperature, up to 0.1°C, in both arms

Timeline

• Start date: 2017-11-01
• Primary completion: 2022-11-26
• Completion: 2023-01-18
• First posted: 2018-06-07
• Last updated: 2024-09-19

Locations

1 site across 1 country: Belgium