NCT03547063

Responses to Appetite and Taste in the Brain Circuits That Control Eating Behaviour

Responses to Appetite and Taste in the Brain Circuits That Control Eating Behaviour: An fMRI Study Evaluating Brain Structure, Connectivity and Responses to Taste Across Different Body Weight Categories and in Response to Weight Loss

• Status: Suspended
• Phase: —
• Study type: Observational
• Enrollment: 75 (estimated)
• Sponsor: University College, London · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to gain insight into brain structure and the neural networks that control taste and eating behaviour in patients with severe obesity undergoing a primary sleeve gastrectomy (SG) or a lifestyle intervention for weight loss compared with normal weight individuals, using functional magnetic resonance imaging (fMRI).

Detailed description

This is an observational study aiming to gain insight into brain structure and the neural networks that control taste and eating behaviour in patients with severe obesity undergoing a primary sleeve gastrectomy (SG) or a lifestyle intervention for weight loss compared with normal weight individuals using functional magnetic resonance imaging (fMRI). Drops of liquid foods and a control solution will be delivered to the participants' mouth during fMRI scanning. Body weight, gut hormones from serial blood samples, appetite scores and taste will be assessed at each study visit.

Conditions

• Obesity

Timeline

• Start date: 2018-12-18
• Primary completion: 2021-12-01
• Completion: 2022-12-01
• First posted: 2018-06-06
• Last updated: 2021-01-20

Locations

1 site across 1 country: United Kingdom