NCT03543488

Neuromusuclar Adaptations in the Rheumatoid Arthritis Disease

Neuromusuclar Responses and Functional Outcomes in Middle-aged Women With Rheumatoid Arthritis.

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 70 (actual)
• Sponsor: Federal University of Rio Grande do Sul · Academic / Other
• Sex: Female
• Age: 25 Years – 75 Years
• Healthy volunteers: Accepted

Summary

Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes joint inflammation and progressive joint destruction. Rheumatoid cachexia is one of the structural manifestations of RA, and consists of a reduction in muscle mass, due to an increased muscle protein catabolism induced by inflammatory cytokines. This muscle mass loss generates an impairment in physical function and functional capacity in RA patients. The aim of study was to verify neuromuscular and functional responses in middle-aged women with RA compared to paired healthy women.

Conditions

• Arthritis, Rheumatoid
• Muscular Weakness

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Neuromuscular and functional capacity tests	The Timed Up and Go test; Maximal knee-extensor muscle strength (isometric and concentric tests) was measured with a Biodex System 3 dynamometer; A B-mode ultrasonography system with a linear-array probe (60 mm, 7.5 MHz) was used to determine VL and RF muscle thickness, pennation angle, fascicle length and tendon CSA. Measurements were obtained with the volunteer seated in the dynamometer, during isometric contraction at 90° of knee flexion. An 8-channel EMG system was synchronized with the dynamometer through a Windaq data acquisition system and used to evaluate the vastus lateralis and rectus femoris electrical activity during isometric knee-extensor tests.

Timeline

• Start date: 2013-06-01
• Primary completion: 2013-11-20
• Completion: 2014-03-03
• First posted: 2018-06-01
• Last updated: 2018-06-01