NCT03542552

Nifedipine Versus Magnesium Sulfate for Prevention of Preterm Labor in Symptomatic Placenta Previa

Oral Nifedipine Versus Intravenous Magnesium Sulfate for Prevention of Preterm Labor in Symptomatic Placenta Previa: Randomized Controlled Trial.

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 176 (actual)
• Sponsor: Assiut University · Academic / Other
• Sex: Female
• Age: —
• Healthy volunteers: Not accepted

Summary

Antepartum hemorrhage is defined as bleeding from or within the female genital tract, occurring from 28+0 weeks of pregnancy and till delivery of the fetus. it occurs in 3-5% of pregnancies and is an important cause of perinatal and maternal morbidity and mortality worldwide

Detailed description

There are many tocolytic agents may have a role in conservative management of placenta previa such as magnesium sulfate, calcium channel blockers and β-sympathormimetics. In 2004 Sharma suggests that ritodrine hydrochloride in patients with symptomatic placenta previa tends to prolong the pregnancy and result in an increase in birth weight of the babies without causing any adverse effect on the mother and fetus

Conditions

• Placenta Previa

Interventions

Type	Name	Description
DRUG	Magnesium Sulfate	Patients received intravenous 6 g bolus MgSO4 20% followed by a 2 g/h infusion
DRUG	Nifedipine	received oral nifedipine 10 mg every 20 minutes for three doses, followed by 10 mg orally every 6 hours

Timeline

• Start date: 2018-06-01
• Primary completion: 2021-03-30
• Completion: 2021-04-30
• First posted: 2018-05-31
• Last updated: 2021-07-28

Locations

1 site across 1 country: Egypt