NCT03542409

Safety and Feasibility of Preoperative and Intraoperative Image-Guided Resection of Gliomas

Assessment of Safety and Feasibility of Preoperative and Intraoperative Image-Guided Resection of Gliomas and Tumor Region-Specific Biomarker Correlation

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 53 (actual)
• Sponsor: University of Utah · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study evaluates the use of specialized magnetic resonance imaging (MRI) techniques including magnetic resonance (MR) perfusion and 2-hydroxyglutarate (2HG) spectroscopy in the surgical treatment of gliomas. Cohort 1 participants will undergo an MR perfusion scan or 2-HG spectroscopy prior to surgery and intra-operatively. Cohort 2 participants will only undergo standard of care imaging and tumor acquisition. Participant participation will end at the completion of surgery and will be transitioned to standard of care follow-up.

Conditions

• Brain Tumor Adult

Interventions

Type	Name	Description
OTHER	MR Perfusion Scan	MR perfusion scan before and during surgery.
OTHER	2HG Spectroscopy Scan	2HG spectroscopy scan before and during surgery.
OTHER	Standard of Care Intraoperative MRI	The standard of care intraoperative MRI sequences used routinely will be sufficient for these 10 new samples.

Timeline

• Start date: 2017-02-15
• Primary completion: 2021-10-28
• Completion: 2026-07-01
• First posted: 2018-05-31
• Last updated: 2025-11-20

Locations

1 site across 1 country: United States