NCT03532360

Peanut and Tree Nut Desensitization

Peanut/Tree Nut Desensitization and Induction of Tolerance in Children

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 51 (estimated)
• Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre · Academic / Other
• Sex: All
• Age: 2 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

this study evaluates whether tolerance to peanuts and tree nuts can be induced in patients through a process of oral immunotherapy. Participants will be randomized into groups receiving oral immunotherapy and a control group that will receive no intervention

Detailed description

The investigators are proposing to initiate a study assessing a common desensitization protocol for peanut/tree nut allergy. This study would enable the investigators to better determine the potential benefit of desensitization in individuals with peanut/tree nut allergy. More specifically, the investigators will address the following research objectives: Objectives A. To develop a protocols for peanut/tree nut desensitization with high (300mg) and low (30mg maintenance dose). B. To determine the rate of desensitization to peanut/tree nut. C. To characterize predictors of successful desensitization. D. To characterize molecular mechanisms involved in the process of desensitization These objectives will be evaluated through a randomized controlled trial

Conditions

• Peanut Allergy
• Tree Nut Allergy

Interventions

Type	Name	Description
OTHER	Oral immunotherapy	Starting from a very low level and over a period of several months, participants receive escalating doses of the food to which they are allergic

Timeline

• Start date: 2018-02-19
• Primary completion: 2024-06-26
• Completion: 2027-12-31
• First posted: 2018-05-22
• Last updated: 2025-02-06

Locations

2 sites across 1 country: Canada