NCT03530436

Comparison of Curcumin Bioavailability

Comparison of the Bioavailability of Different Curcumin Formulations in Healthy Humans

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: University of Hohenheim · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

The curcuminoids curcumin, demethoxycurcumin and bisdemethoxycurcumin can be found in the rhizome of turmeric (Curcuma longa). Curcumin is widespread used for colouring foods. Based on its natural low bioavailability and the number of its effects on human health, several approaches such as increasing its water solubility or inhibiting its metabolism were taken to improve its bioavailability. Pharmacokinetics of curcumin from various supplements using those different mechanisms have been compared to the one of native curcumin. The investigator's study here will compare the bioavailability of curcumin from eight different curcumin formulations with native curcumin and between themselves. The study will folllow a single dose (in form of curcumin formulations, normalized to 207 mg curcumin), placebo-controlled, randomized, double-blind, nine-armed crossover study design with ≥ 1-week washout periods. Plasma samples will be collected at intervals up to 24 hours after intake. Investigators will compare the pharmacokinetics between the different curcumin formulations and to native curcumin.

Conditions

• Safety After Oral Intake
• Pharmacokinetics After Oral Intake

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Native turmeric extract	207 mg curcumin
DIETARY_SUPPLEMENT	Native turmeric extract with 7-9% volatile turmeric oils	207 mg curcumin
DIETARY_SUPPLEMENT	Turmeric extract plus mixture of phytochemicals	207 mg curcumin
DIETARY_SUPPLEMENT	Cyclodextrin complex of curcuminoids	207 mg curcumin
DIETARY_SUPPLEMENT	Turmeric oleoresin	207 mg curcumin
DIETARY_SUPPLEMENT	Liposomal curcumin	207 mg curcumin
DIETARY_SUPPLEMENT	Phytosomal curcumin	207 mg curcumin
DIETARY_SUPPLEMENT	Micellar turmeric extract	207 mg curcumin

Timeline

• Start date: 2018-06-07
• Primary completion: 2018-08-10
• Completion: 2018-11-07
• First posted: 2018-05-21
• Last updated: 2019-01-10

Locations

1 site across 1 country: Germany