NCT03529318

Mucosal Innate Immune Activation in Chronic Intestinal Disorders

• Status: Withdrawn
• Phase: —
• Study type: Observational
• Enrollment: 0 (actual)
• Sponsor: University of Arkansas · Academic / Other
• Sex: All
• Age: 18 Years – 99 Years
• Healthy volunteers: Not accepted

Summary

Crohn's disease and ulcerative colitis are types of chronic intestinal disorder called inflammatory bowel diseases (IBD) that can affect the small and large bowel causing symptoms of abdominal pain, diarrhea, blood in the stool, and weight loss. Irritable bowel syndrome (IBS) is a milder form of IBD, with symptoms of abdominal pain, bloating, diarrhea or constipation, and blood in the stool. It is not known what causes diseases such as IBD and IBS. This study will look at the events in the gut that leads to leaky gut and inflammation in patients with IBD and IBS. The study will also see if medications such as rifaximin and mesalamine may reduce the amount of leaky gut.

Conditions

• Irritable Bowel Syndrome
• Inflammatory Bowel Diseases

Interventions

Type	Name	Description
PROCEDURE	Biopsies from endoscopy	1\) Patients scheduled for endoscopy (EGD or colonoscopy) for IBD will be consented to allow physicians who are performing endoscopies to take additional biopsies and blood samples for "research purposes".

Timeline

• Start date: 2018-09-01
• Primary completion: 2019-10-18
• Completion: 2019-10-18
• First posted: 2018-05-18
• Last updated: 2019-10-22

Locations

1 site across 1 country: United States