NCT03528226

Exercise Training and Endothelial Function in Type 1 Diabetes

Impact of Exercise Training on Endothelial Function in Adults With Type 1 Diabetes

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 34 (estimated)
• Sponsor: University Hospital, Lille · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

Endothelial dysfunction and vasoreactivity disorders are early subclinical complications of type 1 diabetes (T1D). In a preventive setting, in T1D patients still free of complications, the research of non-pharmacological interventions to improve endothelial function appears fundamental. In this randomized controlled trial, the effects of exercise training on endothelial function will be evaluated in T1D adults. Secondary objectives are to evaluate the exercise training effects on the micro and macrovascular function and exercise-induced tissue vasoreactivity and their possible neurometabolic consequences. An improvement in vascular function, particularly endothelium-dependent, as well as in neurometabolic profile, through this non-pharmacological strategy is expected

Conditions

• Type1diabetes

Interventions

Type	Name	Description
BEHAVIORAL	Exercise Training Procedure	Exercise training: 3 sessions - 2 supervised and 1 unsupervised - per week of 30-60 min at 65% - 80% of maximum heart rate (4 months)
BEHAVIORAL	Normal life procedure	No supervised exercise training during the 4 month period.

Timeline

• Start date: 2019-11-12
• Primary completion: 2026-01-01
• Completion: 2026-01-01
• First posted: 2018-05-17
• Last updated: 2025-12-23

Locations

1 site across 1 country: France