Trials / Completed
CompletedNCT03526289
GIP/GLP-1 Co-Activity in Subjects With Overweight and Type 2 Diabetes: Lowering of Food Intake
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 22 (actual)
- Sponsor
- University Hospital, Gentofte, Copenhagen · Academic / Other
- Sex
- Male
- Age
- 18 Years – 70 Years
- Healthy volunteers
- Not accepted
Summary
The primary aim of the study is to evaluate how GIP receptor activation influence food intake and mechanisms regulating food intake in obese individuals with type 2 diabetes that are in steady treatment with metformin and a GLP-1 receptor agonist.
Detailed description
The study is designed as a double blinded cross-over study with two study days: One day of GIP infusion (for 5 hours) and one day with placebo (saline) infusion (for 5 hours). The primary endpoint is difference in food intake between the two study days. Food intake is examined as amount of food eaten during an ad libitum meal.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| BIOLOGICAL | GIP1-42 infusion | 5-hour GIP1-42 infusion (time point 0-300 minutes) |
| OTHER | Saline | 5-hour infusion of saline (placebo) (time point 0-300 minutes) |
Timeline
- Start date
- 2017-11-08
- Primary completion
- 2018-10-24
- Completion
- 2018-10-24
- First posted
- 2018-05-16
- Last updated
- 2018-12-05
Locations
1 site across 1 country: Denmark
Source: ClinicalTrials.gov record NCT03526289. Inclusion in this directory is not an endorsement.