NCT03526081

Absorption, Metabolism and Excretion of Apigenin and Apigenin Glycosides

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 17 (actual)
• Sponsor: University of California, Davis · Academic / Other
• Sex: Male
• Age: 25 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Probe dietary intervention study in healthy young adult males to evaluate the concentration of apigenin derived metabolites in plasma and urine after single acute intakes of different apigenin-containing test materials.

Detailed description

Flavonoids, including the sub groups of Flavones (FO) are plant-derived compounds commonly present in the human diet. Examples of FO-containing foods and beverages are parsley, celery, and chamomile. The study described below will provide initial information of apigenin derived metabolites in humans. The investigators suggest the information that will be obtained from the outlined work will be particularly timely given increasing interest in the putative health effects of FO intake in humans. This study consisted of two parts. The first part consisted of a probe study in which the investigators investigated the absorption and metabolism from four flavone-containing test products. The second phase investigated absorption and metabolism after the intake of a flavone-containing parsley drink.

Conditions

• Healthy

Interventions

Type	Name	Description
OTHER	Chamomile Tea	Chamomile Tea in 300mL hot water
OTHER	Parsley based drink	3.2 g dried parsley in 300mL hot water
OTHER	Parsley Yogurt	3.2 g dried parsley in 100g plain yogurt
OTHER	Apigenin	Apigenin capsule mixed with 300mL hot water
OTHER	Parsley-based drink (II)	3.2 g dried parsley in 300mL hot water

Timeline

• Start date: 2015-01-20
• Primary completion: 2016-07-30
• Completion: 2016-07-30
• First posted: 2018-05-16
• Last updated: 2019-05-23

Locations

2 sites across 1 country: United States