NCT03524079

Right Ventricle Morphology and Hemodynamics in BrS

Morphological and Functional Characteristics of the Right Ventricle in Patients With Brugada Syndrome

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 60 (actual)
• Sponsor: IRCCS Policlinico S. Donato · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The study purpose is to evaluate the morphological, functional and electrophysiological characteristics of the right ventricle before and after ajmaline in patients diagnosed with Brugada syndrome as well as to correlate CMR findings and substrate size.

Detailed description

All consecutive patients with either spontaneous or ajmaline-induced BrS-ECG pattern will be screened. A total of 30 BrS patients and 30 normal age, sex and BSA matched normal controls will be selected and enrolled. Patients will perform cardiac magnetic resonance imaging to evaluate and compare morphological and functional characteristics of the 2 groups before and after ajmaline. BrS patients will also perform a standardized programmed ventricular stimulation protocol and electroanatomical mapping to determine the substrate size.

Conditions

• Brugada Syndrome

Interventions

Type	Name	Description
DRUG	Ajmaline 17-(Chloroacetate) Monohydrochloride	Ajmaline 17-(Chloroacetate) Monohydrochloride(1mg/kg in 5 minutes)

Timeline

• Start date: 2018-04-19
• Primary completion: 2019-11-08
• Completion: 2019-11-09
• First posted: 2018-05-14
• Last updated: 2021-05-18

Locations

1 site across 1 country: Italy