NCT03522922

Efficacy of Microneedling With Topical Vitamin C in Treatment of Acne Scarring

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Sohag University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study aimed to evaluate the efficacy of dermaroller and topical vitamin C- either separate or combined- in treatment of post acne scars. prospective randomized clinical trial that was The study was a randomized controlled trial, conducted in Sohag Dermatology outpatient clinic between June 2016 and of February 2018. 30 patients with acne scars were included. All patients were informed about the entire procedure, medication, possible side effects and outcomes. A written informed consent was signed from each participant.

Detailed description

Study population: Each study group included 10 patients. Detailed history and full clinical examination was conducted for each patient. Patients had 6 visits at one month interval to receive treatment and evaluated one month after the end of treatment visits. The first group: Patients received a series of six treatments by dermaroller at 4 weeks interval and no topical anti scar treatment in between sessions. The second group: Received a series of six treatments by dermaroller at 4 weeks interval with the same maneuver and instructions as first group and each session was followed by immediate application of topical vit.C serum plus once daily application in between sessions. The third group: received once daily topical vit.C serum capsule at night for six months. With monthly evaluation. Assessment of patients during visits was as follow: A) Clinical evaluation by B) Photographic documentation C) Patient satisfaction D) Safety assessment

Conditions

• Acne Vulgaris
• Acne Scars

Interventions

Type	Name	Description
DEVICE	Dermaroller	The derma roller used (dermaroller MF8, MT dermaroller Beverly Hills, California USA) is a plastic device with a 12-cm handle that holds a drum-shaped cylinder at the end, similar to a small paint roller, 2 cm in diameter and 2 cm in width. The surface of the cylinder holds 192 titanium needles in eight rows. Each 0.25 mm in diameter and 1.5 mm length sterilized by UV/ Gamma rays.
DRUG	Topical Vitamin C	The used vitamin C product was in the form of 17% concentration of L- Ascorbic Acid serum that was encapsulated in gelatinous capsules each contain 1 mg of the serum. The patient instructed to open one capsule and apply its serum content on the treatment area daily at night. This capsule form for topical application help to insure stability of the product and also insure use of equal dose in each application

Timeline

• Start date: 2016-06-01
• Primary completion: 2018-02-01
• Completion: 2018-03-31
• First posted: 2018-05-14
• Last updated: 2018-05-14

Locations

1 site across 1 country: Egypt