NCT03522792

Neurotensin - an Important Regulator of Appetite in Humans?

The Effect of Neurotensin on Appetite, Food Intake, Blood Glucose Regulation, Hormone Secretion, and the Degradation of Neurotensin in Vivo

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 18 (estimated)
• Sponsor: University of Copenhagen · Academic / Other
• Sex: Male
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

Neurotensin (NT) is a gut peptide released postprandially from the small intestine. It is known to exert a range of enterogastrone effects and in animal models it reduces food intake when administered by parenteral routes. This study investigates whether the anorexic effects of NT suggested by animal studies can be translated.

Conditions

• Physiology - Regulation of Appetite and Food Intake

Interventions

Type	Name	Description
OTHER	Neurotensin	Intravenous infusion of neurotensin
OTHER	Saline	Intravenous infusion of saline
OTHER	Ad libitum meal	Participants will be served a large meal serving. They will be instructed to eat until they do not feel hungry anymore.
OTHER	Liquid meal	A standardized mixed liquid meal will be ingested to stimulate endogenous peptide hormone release

Timeline

• Start date: 2018-01-05
• Primary completion: 2019-05-01
• Completion: 2019-12-01
• First posted: 2018-05-11
• Last updated: 2019-11-12

Locations

1 site across 1 country: Denmark